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pentobarbital decreases levels of ponatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Steer clear of Except the coadministration outweighs the feasible hazard of ponatinib underexposure; check for signs of minimized efficacy.fentanyl transmucosal and pentobarbital both increase sedation. Prevent